Chemicals and Drugs

Electron Transport Complex IV

A multisubunit enzyme complex containing CYTOCHROME A GROUP; CYTOCHROME A3; two copper atoms; and 13 different protein subunits. It is the terminal oxidase complex of the RESPIRATORY CHAIN and collects electrons that are transferred from the reduced CYTOCHROME C GROUP and donates them to molecular OXYGEN, which is then reduced to water. The redox reaction is simultaneously coupled to the transport of PROTONS across the inner mitochondrial membrane.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A multisubunit enzyme complex containing CYTOCHROME A GROUP; CYTOCHROME A3; two copper atoms; and 13 different protein subunits. It is the terminal oxidase complex of the RESPIRATORY CHAIN and collects electrons that are transferred from the reduced CYTOCHROME C GROUP and donates them to molecular OXYGEN, which is then reduced to water. The redox reaction is simultaneously coupled to the transport of PROTONS across the inner mitochondrial membrane.

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Classification

Broader headings

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See Also

MeSH Record

Synonyms

22 entry terms
  • Cytochrome Oxidase
  • Cytochrome-c Oxidase
  • Cytochrome-c Oxidase (Complex IV)
  • Ferrocytochrome c Oxygen Oxidoreductase
  • Cytochrome c Oxidase
  • Oxidase, Cytochrome
  • Oxidase, Cytochrome-c
  • Cytochrome Oxidase Subunit III
  • Cytochrome a,a3
  • Cytochrome aa3
  • Cytochrome c Oxidase Subunit VIa
  • Cytochrome-c Oxidase Subunit III
  • Cytochrome-c Oxidase Subunit IV
  • Heme aa3 Cytochrome Oxidase
  • Pre-CTOX p25
  • Signal Peptide p25-Subunit IV Cytochrome Oxidase
  • Subunit III, Cytochrome Oxidase
  • p25 Presequence Peptide-Cytochrome Oxidase
  • Cytochrome c Oxidase Subunit III
  • Cytochrome c Oxidase Subunit IV
  • Signal Peptide p25 Subunit IV Cytochrome Oxidase
  • p25 Presequence Peptide Cytochrome Oxidase

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

spell in titles & translations with lowercase c: cytochrome-c oxidase

MeSH Record

History Note

2004(1963); for SIGNAL PEPTIDE P25-SUBUNIT IV CYTOCHROME OXIDASE use CYTOCHROME C OXIDASE (NM) 1988-2001; for CYTOCHROME OXIDASE SUBUNIT III use CYTOCHROME C OXIDASE (NM) 1998-2001

MeSH Hierarchy

Tree Numbers

  1. D05.500w.562w.374
  2. D08.811w.600w.250.687
  3. D08.811w.682w.285
  4. D12.776w.157w.530w.450w.250.875w.304
  5. D12.776w.543w.277.687
  6. D12.776w.543w.585w.450w.250.875w.484

MeSH Record

NLM Classification

QU 140

AMA Style

References

  1. National Library of Medicine. Electron Transport Complex IV. Medical Subject Headings (MeSH). 2026. Unique ID D003576. http://id.nlm.nih.gov/mesh/2026/D003576
  2. Electron Transport Complex IV. In: Wikidata. https://www.wikidata.org/wiki/Q22327118