Diseases

Endodermal Sinus Tumor

An unusual and aggressive tumor of germ-cell origin that reproduces the extraembryonic structures of the early embryo. It is the most common malignant germ cell tumor found in children. It is characterized by a labyrinthine glandular pattern of flat epithelial cells and rounded papillary processes with a central capillary (Schiller-Duval body). The tumor is rarely bilateral. Before the use of combination chemotherapy, the tumor was almost invariably fatal. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1189)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An unusual and aggressive tumor of germ-cell origin that reproduces the extraembryonic structures of the early embryo. It is the most common malignant germ cell tumor found in children. It is characterized by a labyrinthine glandular pattern of flat epithelial cells and rounded papillary processes with a central capillary (Schiller-Duval body). The tumor is rarely bilateral. Before the use of combination chemotherapy, the tumor was almost invariably fatal. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1189)

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

7 entry terms
  • Yolk Sac Tumor
  • Endodermal Sinus Tumors
  • Tumor, Endodermal Sinus
  • Tumor, Yolk Sac
  • Tumors, Endodermal Sinus
  • Tumors, Yolk Sac
  • Yolk Sac Tumors

MeSH Record

Aspects Covered

39 allowable subheadings

Indexed with the subheadings blood, blood supply, cerebrospinal fluid, chemically induced, chemistry, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, secondary, surgery, therapy, ultrastructure, urine, veterinary, virology.

MeSH Record

Indexing Annotation

coordinate with precoordinated organ/neoplasm term

MeSH Record

History Note

94; was see MESONEPHROMA 1979-93; YOLK SAC TUMOR was see MESONEPHROMA 1979-93

MeSH Record

Previous Indexing

  • Mesonephroma (1968-1993)

MeSH Hierarchy

Tree Number

  1. C04w.557.465.510.350w

AMA Style

References

  1. National Library of Medicine. Endodermal Sinus Tumor. Medical Subject Headings (MeSH). 2026. Unique ID D018240. http://id.nlm.nih.gov/mesh/2026/D018240
  2. Endodermal Sinus Tumor. In: Wikipedia. https://en.wikipedia.org/wiki/Endodermal_sinus_tumor
  3. Endodermal Sinus Tumor. In: Wikidata. https://www.wikidata.org/wiki/Q3542021