Chemicals and Drugs

Endothelial Growth Factors

These growth factors are soluble mitogens secreted by a variety of organs. The factors are a mixture of two single chain polypeptides which have affinity to heparin. Their molecular weight are organ and species dependent. They have mitogenic and chemotactic effects and can stimulate endothelial cells to grow and synthesize DNA. The factors are related to both the basic and acidic FIBROBLAST GROWTH FACTORS but have different amino acid sequences.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

These growth factors are soluble mitogens secreted by a variety of organs. The factors are a mixture of two single chain polypeptides which have affinity to heparin. Their molecular weight are organ and species dependent. They have mitogenic and chemotactic effects and can stimulate endothelial cells to grow and synthesize DNA. The factors are related to both the basic and acidic FIBROBLAST GROWTH FACTORS but have different amino acid sequences.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

14 entry terms
  • ECDGF
  • Endo-GF
  • Endothelial Cell-Derived Growth Factors
  • Endothelial Growth Factor
  • Endothelial Growth Factor Polypeptides
  • Endothelial Cell Derived Growth Factors
  • Growth Factor, Endothelial
  • Growth Factors, Endothelial
  • alpha-Endothelial Growth Factor
  • beta-Endothelial Growth Factor
  • Growth Factor, alpha-Endothelial
  • Growth Factor, beta-Endothelial
  • alpha Endothelial Growth Factor
  • beta Endothelial Growth Factor

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

do not confuse with EGF; (EPIDERMAL GROWTH FACTOR)

MeSH Record

History Note

91

MeSH Record

Previous Indexing

  • Fibroblast Growth Factor (1984-1990)
  • Growth Substances (1966-1983)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.276.390
  2. D12.776w.467.390
  3. D23.529.390

AMA Style

References

  1. National Library of Medicine. Endothelial Growth Factors. Medical Subject Headings (MeSH). 2026. Unique ID D016228. http://id.nlm.nih.gov/mesh/2026/D016228
  2. Endothelial Growth Factors. In: Wikidata. https://www.wikidata.org/wiki/Q77303159