Chemicals and Drugs

Enhancer of Zeste Homolog 2 Protein

A histone-lysine N-methyltransferase and catalytic subunit of Polycomb Repressive Complex 2. It methylates LYSINE 9 (H3K9me) and LYSINE 27 (H3K27me) of HISTONE H3, leading to transcriptional repression of the affected target gene. EZH2 also methylates non-histone proteins such as GATA4 TRANSCRIPTION FACTOR and the nuclear receptor RORA. It regulates CIRCADIAN CLOCKS via histone methylation of circadian protein gene PROMOTER REGIONS, and its repressive activity is also important for the identity and differentiation of EMBRYONIC STEM CELLS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A histone-lysine N-methyltransferase and catalytic subunit of Polycomb Repressive Complex 2. It methylates LYSINE 9 (H3K9me) and LYSINE 27 (H3K27me) of HISTONE H3, leading to transcriptional repression of the affected target gene. EZH2 also methylates non-histone proteins such as GATA4 TRANSCRIPTION FACTOR and the nuclear receptor RORA. It regulates CIRCADIAN CLOCKS via histone methylation of circadian protein gene PROMOTER REGIONS, and its repressive activity is also important for the identity and differentiation of EMBRYONIC STEM CELLS.

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Synonyms

6 entry terms
  • Enhancer of Zeste Homolog 2
  • Histone-Lysine N-Methyltransferase EZH2
  • Lysine N-Methyltransferase-6
  • EZH2, Histone-Lysine N-Methyltransferase
  • Histone Lysine N Methyltransferase EZH2
  • Lysine N Methyltransferase 6

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Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017 (2005)

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Tree Numbers

  1. D05.500w.781w.750w.250
  2. D08.811w.913w.555.500w.800.200w.500.500w.500
  3. D12.776w.660w.235.600w.200w.250
  4. D12.776w.664w.235.800w.200w.250
  5. D12.776w.930w.780.890w.200w.250

AMA Style

References

  1. National Library of Medicine. Enhancer of Zeste Homolog 2 Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000071221. http://id.nlm.nih.gov/mesh/2026/D000071221
  2. Enhancer of Zeste Homolog 2 Protein. In: Wikidata. https://www.wikidata.org/wiki/Q21097530