Chemicals and Drugs

Epoprostenol

A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).

Chemical Identity

Chemical Information

Molecular Formula
C20H32O5
Molecular Weight
352.5 g/mol
CAS Registry No.
35121-78-9
IUPAC Name
(5Z)-5-[(3aR,4R,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]pentanoic acid
InChIKey
KAQKFAOMNZTLHT-OZUDYXHBSA-N
SMILES
CCCCC[C@@H](/C=C/[C@H]1[C@@H](C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O)O
MeSH Unique ID
D011464
Source
PubChem CID 5282411

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

8 entry terms
  • Epoprostanol
  • Prostacyclin
  • Prostaglandin I(2)
  • Prostaglandin I2
  • Epoprostenol Sodium
  • Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer
  • Flolan
  • Veletri

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

1991 (1978); use PROSTAGLANDINS X 1978-1990; for PROSTACYCLIN use PROSTACYCLINS 1978-1993; for PROSTAGLANDIN I2 use PROSTAGLANDINS I2 1982-1993; for PROSTAGLANDIN X use PROSTAGLANDINS X 1991-1993

MeSH Record

Previous Indexing

  • Prostaglandins (1966-1977)

MeSH Hierarchy

Tree Numbers

  1. D10w.251w.355w.255w.550w.550.500w
  2. D23.469.050w.175w.725w.550.500w

AMA Style

References

  1. National Library of Medicine. Epoprostenol. Medical Subject Headings (MeSH). 2026. Unique ID D011464. http://id.nlm.nih.gov/mesh/2026/D011464
  2. Epoprostenol. In: Wikipedia. https://en.wikipedia.org/wiki/Prostacyclin
  3. Epoprostenol. In: Wikidata. https://www.wikidata.org/wiki/Q412050
  4. Epoprostenol. In: PubChem Compound. CID 5282411. https://pubchem.ncbi.nlm.nih.gov/compound/5282411