Chemicals and Drugs

Eptifibatide

Cyclic peptide that acts as a platelet glycoprotein IIB-IIIA antagonist, reversibly inhibiting the binding of FIBRINOGEN; VON WILLEBRAND FACTOR; and other adhesive molecules to the GPIIB-IIIA RECEPTORS of platelets. It is used in the management of UNSTABLE ANGINA and in patients undergoing coronary ANGIOPLASTY and stenting procedures.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Cyclic peptide that acts as a platelet glycoprotein IIB-IIIA antagonist, reversibly inhibiting the binding of FIBRINOGEN; VON WILLEBRAND FACTOR; and other adhesive molecules to the GPIIB-IIIA RECEPTORS of platelets. It is used in the management of UNSTABLE ANGINA and in patients undergoing coronary ANGIOPLASTY and stenting procedures.

Chemical Identity

Chemical Information

Molecular Formula
C35H49N11O9S2
Molecular Weight
832.0 g/mol
CAS Registry No.
188627-80-7
IUPAC Name
2-[(3S,6S,12S,20R,23S)-20-carbamoyl-12-[4-(diaminomethylideneamino)butyl]-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,22-hexaoxo-17,18-dithia-1,4,7,10,13,21-hexazabicyclo[21.3.0]hexacosan-6-yl]acetic acid
InChIKey
CZKPOZZJODAYPZ-LROMGURASA-N
SMILES
C1C[C@H]2C(=O)N[C@@H](CSSCCC(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N2C1)CC3=CNC4=CC=CC=C43)CC(=O)O)CCCCN=C(N)N)C(=O)N
MeSH Unique ID
D000077542
Source
PubChem CID 448812

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

5 entry terms
  • 7H-Pyrrolo(2,1-g)(1,2,5,8,11,14,17,20)dithiahexaazacyclotricosine-17-acetic acid, 3-(aminocarbonyl)-11-(4-((aminoiminomethyl)amino)butyl)docosahydro-20-(1H-indol-3-ylmethyl)-1,9,12,15,18,21-hexaoxo-, (3R,11S,17S,20S,25aS)-
  • Epifibatide
  • Epifibratide
  • Integrelin
  • Integrilin

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1994)

MeSH Hierarchy

Tree Number

  1. D12.644w.641w.366w

AMA Style

References

  1. National Library of Medicine. Eptifibatide. Medical Subject Headings (MeSH). 2026. Unique ID D000077542. http://id.nlm.nih.gov/mesh/2026/D000077542
  2. Eptifibatide. In: Wikipedia. https://en.wikipedia.org/wiki/Eptifibatide
  3. Eptifibatide. In: Wikidata. https://www.wikidata.org/wiki/Q2295855
  4. Eptifibatide. In: PubChem Compound. CID 448812. https://pubchem.ncbi.nlm.nih.gov/compound/448812