Chemicals and Drugs

Escin

Pentacyclic triterpene saponins, biosynthesized from protoaescigenin and barringtogenol, occurring in the seeds of AESCULUS. It inhibits edema formation and decreases vascular fragility.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Pentacyclic triterpene saponins, biosynthesized from protoaescigenin and barringtogenol, occurring in the seeds of AESCULUS. It inhibits edema formation and decreases vascular fragility.

Chemical Identity

Chemical Information

Molecular Formula
C55H86O24
Molecular Weight
1131.3 g/mol
CAS Registry No.
11072-93-8
IUPAC Name
6-[[9-acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-(2-methylbut-2-enoyloxy)-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3,5-bis[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxane-2-carboxylic acid
InChIKey
AXNVHPCVMSNXNP-UHFFFAOYSA-N
SMILES
CC=C(C)C(=O)OC1C(C2(C(CC1(C)C)C3=CCC4C5(CCC(C(C5CCC4(C3(CC2O)C)C)(C)CO)OC6C(C(C(C(O6)C(=O)O)OC7C(C(C(C(O7)CO)O)O)O)O)OC8C(C(C(C(O8)CO)O)O)O)C)CO)OC(=O)C
MeSH Unique ID
D004928
Source
PubChem CID 4555259

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

16 entry terms
  • Aescin
  • Escina
  • Eskuzan
  • Aescusan
  • Fepalitan
  • Feparil
  • Flebostasin
  • Opino
  • Reparil
  • beta-Aescin
  • beta-Escin
  • opino-biomo
  • beta Aescin
  • beta Escin
  • opino biomo
  • opinobiomo

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(75); was see under SAPONINS 1975-90

MeSH Record

Previous Indexing

  • Glycosides (1971-1974)
  • Saponins (1971-1975)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.849w.919w.530.333
  2. D09w.408w.782w.250

AMA Style

References

  1. National Library of Medicine. Escin. Medical Subject Headings (MeSH). 2026. Unique ID D004928. http://id.nlm.nih.gov/mesh/2026/D004928
  2. Escin. In: Wikidata. https://www.wikidata.org/wiki/Q381866
  3. Escin. In: PubChem Compound. CID 4555259. https://pubchem.ncbi.nlm.nih.gov/compound/4555259