Chemicals and Drugs

Estrone

An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.

Chemical Identity

Chemical Information

Molecular Formula
C18H22O2
Molecular Weight
270.4 g/mol
CAS Registry No.
53-16-7
IUPAC Name
(8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
InChIKey
DNXHEGUUPJUMQT-CBZIJGRNSA-N
SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CCC4=C3C=CC(=C4)O
MeSH Unique ID
D004970
Source
PubChem CID 5870

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

8 entry terms
  • Estrone, (+-)-Isomer
  • Estrone, (8 alpha)-Isomer
  • Estrone, (9 beta)-Isomer
  • Estrovarin
  • Folliculin (Hormone)
  • Kestrone
  • Unigen
  • Wehgen

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Hierarchy

Tree Numbers

  1. D04w.210.500w.365.415.414w
  2. D04w.210.500w.578.502w.497w
  3. D06.472w.040.502w.497w
  4. D06.472w.334.851w.437.996w

MeSH Record

NLM Classification

WP 522

AMA Style

References

  1. National Library of Medicine. Estrone. Medical Subject Headings (MeSH). 2026. Unique ID D004970. http://id.nlm.nih.gov/mesh/2026/D004970
  2. Estrone. In: Wikipedia. https://en.wikipedia.org/wiki/Estrone
  3. Estrone. In: Wikidata. https://www.wikidata.org/wiki/Q414986
  4. Estrone. In: PubChem Compound. CID 5870. https://pubchem.ncbi.nlm.nih.gov/compound/5870