Chemicals and Drugs

Ethambutol

An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863)

Chemical Identity

Chemical Information

Molecular Formula
C10H24N2O2
Molecular Weight
204.31 g/mol
CAS Registry No.
74-55-5
IUPAC Name
(2S)-2-[2-[[(2S)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol
InChIKey
AEUTYOVWOVBAKS-UWVGGRQHSA-N
SMILES
CC[C@@H](CO)NCCN[C@@H](CC)CO
MeSH Unique ID
D004977
Source
PubChem CID 14052

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

12 entry terms
  • Dexambutol
  • EMB-Fatol
  • EMB-Hefa
  • Etambutol Llorente
  • Ethambutol Hydrochloride
  • Etibi
  • Miambutol
  • Myambutol
  • EMB Fatol
  • EMB Hefa
  • Hydrochloride, Ethambutol
  • Llorente, Etambutol

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

68(63)

MeSH Hierarchy

Tree Number

  1. D02w.092w.782w.258w.368.265w

MeSH Record

NLM Classification

QV 268

AMA Style

References

  1. National Library of Medicine. Ethambutol. Medical Subject Headings (MeSH). 2026. Unique ID D004977. http://id.nlm.nih.gov/mesh/2026/D004977
  2. Ethambutol. In: Wikipedia. https://en.wikipedia.org/wiki/Ethambutol
  3. Ethambutol. In: Wikidata. https://www.wikidata.org/wiki/Q412318
  4. Ethambutol. In: PubChem Compound. CID 14052. https://pubchem.ncbi.nlm.nih.gov/compound/14052