Diseases

Euthyroid Sick Syndromes

Conditions of abnormal THYROID HORMONES release in patients with apparently normal THYROID GLAND during severe systemic illness, physical TRAUMA, and psychiatric disturbances. It can be caused by the loss of endogenous hypothalamic input or by exogenous drug effects. The most common abnormality results in low T3 THYROID HORMONE with progressive decrease in THYROXINE; (T4) and TSH. Elevated T4 with normal T3 may be seen in diseases in which THYROXINE-BINDING GLOBULIN synthesis and release are increased.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Conditions of abnormal THYROID HORMONES release in patients with apparently normal THYROID GLAND during severe systemic illness, physical TRAUMA, and psychiatric disturbances. It can be caused by the loss of endogenous hypothalamic input or by exogenous drug effects. The most common abnormality results in low T3 THYROID HORMONE with progressive decrease in THYROXINE; (T4) and TSH. Elevated T4 with normal T3 may be seen in diseases in which THYROXINE-BINDING GLOBULIN synthesis and release are increased.

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Classification

Broader headings

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See Also

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Synonyms

15 entry terms
  • Non-Thyroidal Illness Syndrome
  • Sick Euthyroid Syndrome
  • Euthyroid Sick Syndrome
  • Non Thyroidal Illness Syndrome
  • Syndrome, Non-Thyroidal Illness
  • Syndrome, Sick Euthyroid
  • Syndromes, Non-Thyroidal Illness
  • High T4 Syndrome
  • Low T3 High T4 Syndrome
  • Low T3 Syndrome
  • Low T3 and Low T4 Syndrome
  • Low T3-High T4 Syndrome
  • Low T3-Low T4 Syndrome
  • High T4 Syndromes
  • Low T3 Low T4 Syndrome

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Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

Indexing Annotation

differentiate from THYROID HORMONE RESISTANCE SYNDROME where no other disease is present

MeSH Record

History Note

87

MeSH Hierarchy

Tree Number

  1. C19w.874w.255w

AMA Style

References

  1. National Library of Medicine. Euthyroid Sick Syndromes. Medical Subject Headings (MeSH). 2026. Unique ID D005067. http://id.nlm.nih.gov/mesh/2026/D005067
  2. Euthyroid Sick Syndromes. In: Wikipedia. https://en.wikipedia.org/wiki/Euthyroid_sick_syndrome
  3. Euthyroid Sick Syndromes. In: Wikidata. https://www.wikidata.org/wiki/Q1378921