Structured Summary
Abstract
A synthetic form of exendin-4, a 39-amino acid peptide isolated from the venom of the GILA MONSTER lizard (Heloderma suspectum). Exenatide increases CYCLIC AMP levels in pancreatic acinar cells and acts as a GLUCAGON-LIKE PEPTIDE-1 RECEPTOR (GLP-1) agonist and incretin mimetic, enhancing insulin secretion in response to increased glucose levels; it also suppresses inappropriate glucagon secretion and slows gastric emptying. It is used as an anti-diabetic and anti-obesity agent.
MeSH Record
Classification
Related Concepts
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
9 entry terms
- AC 2993
- AC 2993 LAR
- Bydureon
- Byetta
- Ex4 Peptide
- Exendin 4
- Exendin-4
- ITCA 650
- Peptide, Ex4
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2019 (1992)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Exenatide. Medical Subject Headings (MeSH). 2026. Unique ID D000077270. http://id.nlm.nih.gov/mesh/2026/D000077270
- Exenatide. In: Wikipedia. https://en.wikipedia.org/wiki/Exenatide
- Exenatide. In: Wikidata. https://www.wikidata.org/wiki/Q417762