Structured Summary
Abstract
An azetidine derivative and ANTICHOLESTEREMIC AGENT that inhibits intestinal STEROL absorption. It is used to reduce total CHOLESTEROL; LDL CHOLESTEROL, and APOLIPOPROTEINS B in the treatment of HYPERLIPIDEMIAS.
Chemical Identity
Chemical Information
- Molecular Formula
- C24H21F2NO3
- Molecular Weight
- 409.4 g/mol
- CAS Registry No.
- 163222-33-1
- IUPAC Name
- (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one
- InChIKey
- OLNTVTPDXPETLC-XPWALMASSA-N
- SMILES
- C1=CC(=CC=C1[C@@H]2[C@H](C(=O)N2C3=CC=C(C=C3)F)CC[C@@H](C4=CC=C(C=C4)F)O)O
- MeSH Unique ID
- D000069438
- Source
- PubChem CID 150311
MeSH Record
Classification
Broader headings
Narrower headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
8 entry terms
- (1-(4-fluorophenyl)-(3R)-(3-(4-fluorophenyl)-(3S)-hydroxypropyl)-(4S)-(4-hydroxyphenyl)-2-azetidinone)
- Ezetimib
- Ezetrol
- SCH 58235
- SCH-58235
- SCH58235
- Zetia
- 58235, SCH
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2016 (1998)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Ezetimibe. Medical Subject Headings (MeSH). 2026. Unique ID D000069438. http://id.nlm.nih.gov/mesh/2026/D000069438
- Ezetimibe. In: Wikipedia. https://en.wikipedia.org/wiki/Ezetimibe
- Ezetimibe. In: Wikidata. https://www.wikidata.org/wiki/Q417997
- Ezetimibe. In: PubChem Compound. CID 150311. https://pubchem.ncbi.nlm.nih.gov/compound/150311