Chemicals and Drugs

FMRFamide

A molluscan neuroactive peptide which induces a fast excitatory depolarizing response due to direct activation of amiloride-sensitive SODIUM CHANNELS. (From Nature 1995; 378(6558): 730-3)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A molluscan neuroactive peptide which induces a fast excitatory depolarizing response due to direct activation of amiloride-sensitive SODIUM CHANNELS. (From Nature 1995; 378(6558): 730-3)

Chemical Identity

Chemical Information

Molecular Formula
C29H42N8O4S
Molecular Weight
598.8 g/mol
CAS Registry No.
64190-70-1
IUPAC Name
(2S)-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-(diaminomethylideneamino)pentanamide
InChIKey
WCSPDMCSKYUFBX-ZJZGAYNASA-N
SMILES
CSCC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N)NC(=O)[C@H](CC2=CC=CC=C2)N
MeSH Unique ID
D019835
Source
PubChem CID 10100083

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

12 entry terms
  • FMRF
  • FMRF-NH2
  • FMRF-amide
  • Phe-Met-Arg-Phe-NH2
  • Phe-Met-Arg-Phe-amide
  • FMRF NH2
  • FMRF amide
  • Phe Met Arg Phe amide
  • FMRFamide, (D-Arg)-Isomer
  • FMRFamide, (D-Met)-Isomer
  • FMRFamide, (D-Phe)-Isomer
  • FMRFamide, (D-phenylalanine)-Isomer

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

98; use FMRFAMIDE (NM) 1978-97

MeSH Record

Previous Indexing

  • Nerve Tissue Proteins (1986-1987)
  • Neuropeptides (1987-1997)
  • Oligopeptides (1978-1986)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.400w.235w
  2. D12.776w.631w.650w.235w

AMA Style

References

  1. National Library of Medicine. FMRFamide. Medical Subject Headings (MeSH). 2026. Unique ID D019835. http://id.nlm.nih.gov/mesh/2026/D019835
  2. FMRFamide. In: Wikipedia. https://en.wikipedia.org/wiki/FMRFamide
  3. FMRFamide. In: Wikidata. https://www.wikidata.org/wiki/Q5426656
  4. FMRFamide. In: PubChem Compound. CID 10100083. https://pubchem.ncbi.nlm.nih.gov/compound/10100083