Structured Summary
Abstract
Activated form of factor XI. In the intrinsic pathway, Factor XI is activated to XIa by factor XIIa in the presence of cofactor HMWK; (HIGH MOLECULAR WEIGHT KININOGEN). Factor XIa then activates factor IX to factor IXa in the presence of calcium.
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Classification
Broader headings
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Synonyms
8 entry terms
- Activated Factor XI
- Blood Coagulation Factor XI, Activated
- Coagulation Factor XIa
- Contact Activation Product
- Factor 11A
- Factor Eleven A
- Factor XI, Activated
- Factor XIa, Coagulation
MeSH Record
Aspects Covered
28 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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Indexing Annotation
/defic = FACTOR XI DEFICIENCY
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History Note
90
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Previous Indexing
- Factor XI (1972-1989)
- Serine Proteinases (1988-1989)
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AMA Style
References
- National Library of Medicine. Factor XIa. Medical Subject Headings (MeSH). 2026. Unique ID D015945. http://id.nlm.nih.gov/mesh/2026/D015945
- Factor XIa. In: Wikidata. https://www.wikidata.org/wiki/Q50259279