Chemicals and Drugs

Fenretinide

A synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at risk of developing contralateral breast cancer. It is also effective as an antineoplastic agent.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at risk of developing contralateral breast cancer. It is also effective as an antineoplastic agent.

Chemical Identity

Chemical Information

Molecular Formula
C26H33NO2
Molecular Weight
391.5 g/mol
CAS Registry No.
65646-68-6
IUPAC Name
(2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenamide
InChIKey
AKJHMTWEGVYYSE-FXILSDISSA-N
SMILES
CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C(=O)NC2=CC=C(C=C2)O)/C)/C
MeSH Unique ID
D017313
Source
PubChem CID 5288209

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

12 entry terms
  • 4-HPR
  • 4-Hydroxyphenylretinamide
  • Fenretinimide
  • N-(4-Hydroxyphenyl)-trans-Retinamide
  • N-(4-Hydroxyphenyl)retinamide
  • 4 Hydroxyphenylretinamide
  • Fenretinide, 13-cis-Isomer
  • MCN-R-1967
  • 13-cis-Isomer Fenretinide
  • Fenretinide, 13 cis Isomer
  • MCN R 1967
  • MCNR1967

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

93; was FENRETINIDE (NM) 1979-92

MeSH Record

Previous Indexing

  • Tretinoin/analogs & derivatives (1979-1992)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.326.271w.665w.202w.495w.270w
  2. D02w.455w.426w.392.368w.367.379.249w.700w.270w
  3. D02w.455w.849w.131w.495w.270w
  4. D23.767w.261w.700w.270w

AMA Style

References

  1. National Library of Medicine. Fenretinide. Medical Subject Headings (MeSH). 2026. Unique ID D017313. http://id.nlm.nih.gov/mesh/2026/D017313
  2. Fenretinide. In: Wikipedia. https://en.wikipedia.org/wiki/Fenretinide
  3. Fenretinide. In: Wikidata. https://www.wikidata.org/wiki/Q5443576
  4. Fenretinide. In: PubChem Compound. CID 5288209. https://pubchem.ncbi.nlm.nih.gov/compound/5288209