Chemicals and Drugs

Fibroblast Growth Factor 1

A 17-kDa single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. It binds to HEPARIN, which potentiates its biological activity and protects it from proteolysis. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages, and also has chemotactic and mitogenic activities. It was originally named acidic fibroblast growth factor based upon its chemical properties and to distinguish it from basic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 2).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A 17-kDa single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. It binds to HEPARIN, which potentiates its biological activity and protects it from proteolysis. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages, and also has chemotactic and mitogenic activities. It was originally named acidic fibroblast growth factor based upon its chemical properties and to distinguish it from basic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 2).

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

10 entry terms
  • Acidic Fibroblast Growth Factor
  • Class I Heparin-Binding Growth Factor
  • FGF-1
  • FGF1
  • Fibroblast Growth Factor, Acidic
  • Fibroblast Growth Factor-1
  • HBGF-1
  • Heparin-Binding Fibroblast Growth Factor Class I
  • Heparin-Binding Growth Factor, Class I
  • Heparin Binding Growth Factor, Class I

MeSH Record

Aspects Covered

31 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2002(1991); for FIBROBLAST GROWTH FACTOR-1 use FIBROBLAST GROWTH FACTOR 1(NM) 1998-2001

MeSH Record

Previous Indexing

  • Fibroblast Growth Factor (1984-1990)
  • Growth Substances (1974-1983)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.276.624w.110w
  2. D12.776w.467.624w.110w
  3. D23.529.624w.110w

AMA Style

References

  1. National Library of Medicine. Fibroblast Growth Factor 1. Medical Subject Headings (MeSH). 2026. Unique ID D016220. http://id.nlm.nih.gov/mesh/2026/D016220
  2. Fibroblast Growth Factor 1. In: Wikipedia. https://en.wikipedia.org/wiki/Fibroblast_growth_factor_1
  3. Fibroblast Growth Factor 1. In: Wikidata. https://www.wikidata.org/wiki/Q5425464