Chemicals and Drugs

Fibroblast Growth Factor 2

A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

13 entry terms
  • Basic Fibroblast Growth Factor
  • Cartilage-Derived Growth Factor
  • Class II Heparin-Binding Growth Factor
  • FGF-2
  • FGF2
  • Fibroblast Growth Factor, Basic
  • Fibroblast Growth Factor-2
  • HBGF-2
  • Heparin-Binding Growth Factor Class II
  • Prostate Epithelial Cell Growth Factor
  • Prostatropin
  • Cartilage Derived Growth Factor
  • FGF 2

MeSH Record

Aspects Covered

31 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2001(1991); for FIBROBLAST GROWTH FACTOR-2 use FIBROBLAST GROWTH FACTOR 2 (NM) 1995; for PROSTATROPIN use FIBROBLAST GROWTH FACTOR 2 (NM) 1986-2001

MeSH Record

Previous Indexing

  • Fibroblast Growth Factor (1984-1990)
  • Growth Substances (1974-1983)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.276.624w.120
  2. D12.776w.467.624w.120
  3. D23.529.624w.120

AMA Style

References

  1. National Library of Medicine. Fibroblast Growth Factor 2. Medical Subject Headings (MeSH). 2026. Unique ID D016222. http://id.nlm.nih.gov/mesh/2026/D016222
  2. Fibroblast Growth Factor 2. In: Wikidata. https://www.wikidata.org/wiki/Q24722430