Chemicals and Drugs

Focal Adhesion Kinase 1

A non-receptor protein tyrosine kinase with PROTEIN PHOSPHATASE 1 regulatory activity that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A non-receptor protein tyrosine kinase with PROTEIN PHOSPHATASE 1 regulatory activity that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

5 entry terms
  • Endogenous Substrate pp120
  • Focal Adhesion-Associated Protein-Tyrosine Kinase pp125FAK
  • Protein Tyrosine Kinase 2
  • p125FAK Protein
  • Focal Adhesion Associated Protein Tyrosine Kinase pp125FAK

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2006(1986)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.725w.049.500
  2. D12.776w.476.568w.049.500
  3. D12.776w.744w.493

AMA Style

References

  1. National Library of Medicine. Focal Adhesion Kinase 1. Medical Subject Headings (MeSH). 2026. Unique ID D051417. http://id.nlm.nih.gov/mesh/2026/D051417
  2. Focal Adhesion Kinase 1. In: Wikidata. https://www.wikidata.org/wiki/Q2744706