Structured Summary
Abstract
Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033)
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Classification
Broader headings
Related Concepts
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MeSH Record
Synonyms
14 entry terms
- Antifolate
- Antifolates
- Dihydrofolate Reductase Inhibitor
- Dihydrofolate Reductase Inhibitors
- Folic Acid Antagonist
- Acid Antagonist, Folic
- Acid Antagonists, Folic
- Antagonist, Folic Acid
- Antagonists, Folic Acid
- Inhibitor, Dihydrofolate Reductase
- Inhibitors, Dihydrofolate Reductase
- Reductase Inhibitor, Dihydrofolate
- Reductase Inhibitors, Dihydrofolate
- Folic Acid Metabolism Inhibitors
MeSH Record
Aspects Covered
22 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
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AMA Style
References
- National Library of Medicine. Folic Acid Antagonists. Medical Subject Headings (MeSH). 2026. Unique ID D005493. http://id.nlm.nih.gov/mesh/2026/D005493
- Folic Acid Antagonists. In: Wikipedia. https://en.wikipedia.org/wiki/Antifolate
- Folic Acid Antagonists. In: Wikidata. https://www.wikidata.org/wiki/Q50573407