Chemicals and Drugs

Forkhead Box Protein L2

A forkhead box transcription factor that is expressed in the developing eyelid and during very early development of the gonad, prior to sex determination. It is essential for development of the ovary and inhibits SOX9 TRANSCRIPTION FACTOR to prevent differentiation to testes. It also induces APOPTOSIS in ovarian cells. Mutations in the FOXL2 gene are associated with BLEPHAROPHIMOSIS; Ptosis, and Epicanthus inversus (BPES with ovarian failure).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A forkhead box transcription factor that is expressed in the developing eyelid and during very early development of the gonad, prior to sex determination. It is essential for development of the ovary and inhibits SOX9 TRANSCRIPTION FACTOR to prevent differentiation to testes. It also induces APOPTOSIS in ovarian cells. Mutations in the FOXL2 gene are associated with BLEPHAROPHIMOSIS; Ptosis, and Epicanthus inversus (BPES with ovarian failure).

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Classification

Broader headings

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MeSH Record

Synonyms

2 entry terms
  • FOXL2 Protein
  • Forkhead Box L2 Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Forkhead Transcription Factors (2006-2017)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.260w.950w.249w.032w
  2. D12.776w.930w.977w.249w.032w

AMA Style

References

  1. National Library of Medicine. Forkhead Box Protein L2. Medical Subject Headings (MeSH). 2026. Unique ID D000074842. http://id.nlm.nih.gov/mesh/2026/D000074842
  2. Forkhead Box Protein L2. In: Wikipedia. https://en.wikipedia.org/wiki/Forkhead_Box_Protein_L2
  3. Forkhead Box Protein L2. In: Wikidata. https://www.wikidata.org/wiki/Q65089657