Structured Summary
Abstract
A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. Grb2 associates with activated EPIDERMAL GROWTH FACTOR RECEPTOR and PLATELET-DERIVED GROWTH FACTOR RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the SON OF SEVENLESS PROTEINS through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS).
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Synonyms
6 entry terms
- Abundant Src Homology Protein
- Growth Factor Receptor-Bound Protein-2
- Growth Factor Receptor Bound Protein 2
- GRB2 Adaptor Protein, Grb3-3 Isoform
- Grb3-3 Adaptor Protein
- GRB2 Adaptor Protein, Grb3 3 Isoform
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Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2006(1992)
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References
- National Library of Medicine. GRB2 Adaptor Protein. Medical Subject Headings (MeSH). 2026. Unique ID D051380. http://id.nlm.nih.gov/mesh/2026/D051380
- GRB2 Adaptor Protein. In: Wikidata. https://www.wikidata.org/wiki/Q5514416