Structured Summary
Abstract
A selective tyrosine kinase inhibitor for the EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) that is used for the treatment of locally advanced or metastatic NON-SMALL CELL LUNG CANCER.
Chemical Identity
Chemical Information
- Molecular Formula
- C22H24ClFN4O3
- Molecular Weight
- 446.9 g/mol
- CAS Registry No.
- 184475-35-2
- IUPAC Name
- N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
- InChIKey
- XGALLCVXEZPNRQ-UHFFFAOYSA-N
- SMILES
- COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4
- MeSH Unique ID
- D000077156
- Source
- PubChem CID 123631
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
4 entry terms
- N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamide
- Iressa
- ZD 1839
- ZD1839
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2019 (2001)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Gefitinib. Medical Subject Headings (MeSH). 2026. Unique ID D000077156. http://id.nlm.nih.gov/mesh/2026/D000077156
- Gefitinib. In: Wikipedia. https://en.wikipedia.org/wiki/Gefitinib
- Gefitinib. In: Wikidata. https://www.wikidata.org/wiki/Q417824
- Gefitinib. In: PubChem Compound. CID 123631. https://pubchem.ncbi.nlm.nih.gov/compound/123631