Chemicals and Drugs

General Transcription Factors

Transcription factors that form transcription initiation complexes on DNA, bind to specific DNA-DIRECTED RNA POLYMERASES and are required to initiate transcription. Although their binding may be localized to distinct sequence and structural motifs within the DNA they are considered non-specific with regard to the specific gene being transcribed.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Transcription factors that form transcription initiation complexes on DNA, bind to specific DNA-DIRECTED RNA POLYMERASES and are required to initiate transcription. Although their binding may be localized to distinct sequence and structural motifs within the DNA they are considered non-specific with regard to the specific gene being transcribed.

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Synonyms

2 entry terms
  • Transcription Factors, General
  • General Transcription Initiation Complex Proteins

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Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003

MeSH Hierarchy

Tree Numbers

  1. D12.776w.260w.775w
  2. D12.776w.930w.930w

AMA Style

References

  1. National Library of Medicine. General Transcription Factors. Medical Subject Headings (MeSH). 2026. Unique ID D035165. http://id.nlm.nih.gov/mesh/2026/D035165
  2. General Transcription Factors. In: Wikipedia. https://en.wikipedia.org/wiki/General_transcription_factor
  3. General Transcription Factors. In: Wikidata. https://www.wikidata.org/wiki/Q2316030