Phenomena and Processes

Genetic Epistasis

A form of gene interaction whereby the expression of one gene interferes with or masks the expression of a different gene or genes. Genes whose expression interferes with or masks the effects of other genes are said to be epistatic to the effected genes. Genes whose expression is affected (blocked or masked) are hypostatic to the interfering genes.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A form of gene interaction whereby the expression of one gene interferes with or masks the expression of a different gene or genes. Genes whose expression interferes with or masks the effects of other genes are said to be epistatic to the effected genes. Genes whose expression is affected (blocked or masked) are hypostatic to the interfering genes.

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Classification

Broader headings

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See Also

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Synonyms

29 entry terms
  • Epistases, Genetic
  • Epistasis, Genetic
  • Gene-Gene Interaction, Epistatic
  • Gene-Gene Interactions, Epistatic
  • Genetic Epistases
  • Non-Allelic Gene Interactions
  • Epistatic Gene-Gene Interaction
  • Epistatic Gene-Gene Interactions
  • Gene Gene Interaction, Epistatic
  • Gene Gene Interactions, Epistatic
  • Gene Interaction, Non-Allelic
  • Gene Interactions, Non-Allelic
  • Interaction, Epistatic Gene-Gene
  • Interaction, Non-Allelic Gene
  • Interactions, Epistatic Gene-Gene
  • Interactions, Non-Allelic Gene
  • Non Allelic Gene Interactions
  • Non-Allelic Gene Interaction
  • Deviation, Epistatic
  • Epistatic Deviation
  • Genes, Epistatic
  • Genes, Hypostatic
  • Interaction Deviation
  • Epistatic Gene
  • Epistatic Genes
  • Gene, Epistatic
  • Gene, Hypostatic
  • Hypostatic Gene
  • Hypostatic Genes

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

79

MeSH Record

Previous Indexing

  • Genes, Dominant (1968-1978)
  • Genetics (1966-1967)
  • Phenotype (1968-1978)

MeSH Hierarchy

Tree Number

  1. G05.308w.207w

AMA Style

References

  1. National Library of Medicine. Genetic Epistasis. Medical Subject Headings (MeSH). 2026. Unique ID D004843. http://id.nlm.nih.gov/mesh/2026/D004843
  2. Genetic Epistasis. In: Wikipedia. https://en.wikipedia.org/wiki/Epistasis
  3. Genetic Epistasis. In: Wikidata. https://www.wikidata.org/wiki/Q751748