Chemicals and Drugs

Ghrelin

A 28-amino acid, acylated, orexigenic peptide that is a ligand for GROWTH HORMONE SECRETAGOGUE RECEPTORS. Ghrelin is widely expressed but primarily in the stomach in the adults. Ghrelin acts centrally to stimulate growth hormone secretion and food intake, and peripherally to regulate energy homeostasis. Its large precursor protein, known as appetite-regulating hormone or motilin-related peptide, contains ghrelin and obestatin.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A 28-amino acid, acylated, orexigenic peptide that is a ligand for GROWTH HORMONE SECRETAGOGUE RECEPTORS. Ghrelin is widely expressed but primarily in the stomach in the adults. Ghrelin acts centrally to stimulate growth hormone secretion and food intake, and peripherally to regulate energy homeostasis. Its large precursor protein, known as appetite-regulating hormone or motilin-related peptide, contains ghrelin and obestatin.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

17 entry terms
  • Appetite-Regulating Hormone
  • GHRL Protein
  • Gastric MLTRP
  • Ghrelin Precursor
  • Ghrelin-Obestatin Preprohormone
  • Motilin-Related Peptide
  • Motilin-Related Peptide Precursor
  • Obestatin
  • PpMTLRP
  • Ppghrelin
  • Appetite Regulating Hormone
  • Ghrelin Obestatin Preprohormone
  • Motilin Related Peptide
  • Motilin Related Peptide Precursor
  • Peptide Precursor, Motilin-Related
  • Precursor, Ghrelin
  • Precursor, Motilin-Related Peptide

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2008 (2000)

MeSH Record

Previous Indexing

  • Growth Hormone-Releasing Hormone (2000-2007)
  • Peptide Hormones (1999-2007)

MeSH Hierarchy

Tree Numbers

  1. D06.472w.699w.301w
  2. D12.644w.548w.322w

AMA Style

References

  1. National Library of Medicine. Ghrelin. Medical Subject Headings (MeSH). 2026. Unique ID D054439. http://id.nlm.nih.gov/mesh/2026/D054439
  2. Ghrelin. In: Wikipedia. https://en.wikipedia.org/wiki/Ghrelin
  3. Ghrelin. In: Wikidata. https://www.wikidata.org/wiki/Q422269