Diseases

Gitelman Syndrome

An inherited renal disorder characterized by defective NaCl reabsorption in the convoluted DISTAL KIDNEY TUBULE leading to HYPOKALEMIA. In contrast with BARTTER SYNDROME, Gitelman syndrome includes hypomagnesemia and normocalcemic hypocalciuria, and is caused by mutations in the thiazide-sensitive SODIUM-POTASSIUM-CHLORIDE SYMPORTERS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An inherited renal disorder characterized by defective NaCl reabsorption in the convoluted DISTAL KIDNEY TUBULE leading to HYPOKALEMIA. In contrast with BARTTER SYNDROME, Gitelman syndrome includes hypomagnesemia and normocalcemic hypocalciuria, and is caused by mutations in the thiazide-sensitive SODIUM-POTASSIUM-CHLORIDE SYMPORTERS.

MeSH Record

Classification

Broader headings

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MeSH Record

See Also

MeSH Record

Synonyms

13 entry terms
  • Familial Hypokalemia-Hypomagnesemia
  • Gitelman's Syndrome
  • Hypokalemia-Hypomagnesemia, Primary Renotubular, with Hypocalciuria
  • Hypomagnesemia-Hypokalemia, Primary Renotubular, with Hypocalciuria
  • Potassium and Magnesium Depletion
  • Primary Renotubular, Hypokalemia-Hypomagnesemia with Hypocalciuria
  • Primary Renotubular, Hypomagnesemia-Hypokalemia with Hypocalciuria
  • Tubular Hypomagnesemia-Hypokalemia with Hypocalcuria
  • Familial Hypokalemia Hypomagnesemia
  • Hypokalemia-Hypomagnesemia, Familial
  • Syndrome, Gitelman
  • Syndrome, Gitelman's
  • Tubular Hypomagnesemia Hypokalemia with Hypocalcuria

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

2007

MeSH Record

Previous Indexing

  • Bartter Syndrome (1994-2006)
  • Hypokalemia (1987-2006)
  • Magnesium (1987-2006)

MeSH Hierarchy

Tree Numbers

  1. C12.050.351.968w.419w.815w.491w
  2. C12.200.777w.419w.815w.491w
  3. C12.950w.419w.815w.491w
  4. C16w.320w.831w.491w

AMA Style

References

  1. National Library of Medicine. Gitelman Syndrome. Medical Subject Headings (MeSH). 2026. Unique ID D053579. http://id.nlm.nih.gov/mesh/2026/D053579
  2. Gitelman Syndrome. In: Wikipedia. https://en.wikipedia.org/wiki/Gitelman_syndrome
  3. Gitelman Syndrome. In: Wikidata. https://www.wikidata.org/wiki/Q1053120