Chemicals and Drugs

Globosides

Glycosphingolipids containing N-acetylglucosamine (paragloboside) or N-acetylgalactosamine (globoside). Globoside is the P antigen on erythrocytes and paragloboside is an intermediate in the biosynthesis of erythrocyte blood group ABH and P 1 glycosphingolipid antigens. The accumulation of globoside in tissue, due to a defect in hexosaminidases A and B, is the cause of Sandhoff disease.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Glycosphingolipids containing N-acetylglucosamine (paragloboside) or N-acetylgalactosamine (globoside). Globoside is the P antigen on erythrocytes and paragloboside is an intermediate in the biosynthesis of erythrocyte blood group ABH and P 1 glycosphingolipid antigens. The accumulation of globoside in tissue, due to a defect in hexosaminidases A and B, is the cause of Sandhoff disease.

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Classification

Broader headings

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Synonyms

6 entry terms
  • Cytolipins
  • Lacto-N-neotetraosylceramide
  • Lacto-N-tetraosylceramide
  • Lactoneotetraosylceramide
  • Lacto N neotetraosylceramide
  • Lacto N tetraosylceramide

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

/biosyn /physiol permitted

MeSH Record

History Note

91(79); was see under GLYCOSPHINGOLIPIDS 1979-90

MeSH Record

Previous Indexing

  • Cerebrosides (1972-1978)
  • Glycolipids (1966-1978)
  • Glycosphingolipids (1975-1978)

MeSH Hierarchy

Tree Numbers

  1. D02w.065w.313w.425w
  2. D09w.400w.410w.420w.525.200w.425w
  3. D10w.390w.470w.675.200w.425w
  4. D10w.570w.877w.360w.612.200w.425w

AMA Style

References

  1. National Library of Medicine. Globosides. Medical Subject Headings (MeSH). 2026. Unique ID D005915. http://id.nlm.nih.gov/mesh/2026/D005915
  2. Globosides. In: Wikipedia. https://en.wikipedia.org/wiki/Globoside
  3. Globosides. In: Wikidata. https://www.wikidata.org/wiki/Q418712