Chemicals and Drugs

Glucose-6-Phosphate Isomerase

An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.

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Classification

Broader headings

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MeSH Record

Synonyms

16 entry terms
  • Glucosephosphate Isomerase
  • Isomerase, Glucose 6 Phosphate
  • Phosphoglucose Isomerase
  • Phosphohexose Isomerase
  • Glucose 6 Phosphate Isomerase
  • Isomerase, Glucose-6-Phosphate
  • Isomerase, Glucosephosphate
  • Isomerase, Phosphoglucose
  • Isomerase, Phosphohexose
  • Autocrine Motility Factor
  • Neuroleukin
  • Tumor Autocrine Motility Factor
  • Tumor-Cell Autocrine Motility Factor
  • Factor, Autocrine Motility
  • Motility Factor, Autocrine
  • Tumor Cell Autocrine Motility Factor

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

1998(1965)

MeSH Hierarchy

Tree Number

  1. D08.811w.399w.475.200.350w

AMA Style

References

  1. National Library of Medicine. Glucose-6-Phosphate Isomerase. Medical Subject Headings (MeSH). 2026. Unique ID D005956. http://id.nlm.nih.gov/mesh/2026/D005956
  2. Glucose-6-Phosphate Isomerase. In: Wikipedia. https://en.wikipedia.org/wiki/Glucose-6-phosphate_isomerase
  3. Glucose-6-Phosphate Isomerase. In: Wikidata. https://www.wikidata.org/wiki/Q418097