Chemicals and Drugs

Glucosylceramidase

A glycosidase that hydrolyzes a glucosylceramide to yield free ceramide plus glucose. Deficiency of this enzyme leads to abnormally high concentrations of glucosylceramide in the brain in GAUCHER DISEASE. EC 3.2.1.45.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A glycosidase that hydrolyzes a glucosylceramide to yield free ceramide plus glucose. Deficiency of this enzyme leads to abnormally high concentrations of glucosylceramide in the brain in GAUCHER DISEASE. EC 3.2.1.45.

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Classification

Broader headings

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MeSH Record

See Also

MeSH Record

Synonyms

17 entry terms
  • Acid beta-Glucosidase
  • Glucocerebrosidase
  • Glucocerebroside beta-Glucosidase
  • Glucosyl Ceramidase
  • Glucosylceramide beta-Glucosidase
  • Glucosylsphingosine Glucosyl Hydrolase
  • beta-Glucocerebrosidase
  • Acid beta Glucosidase
  • Ceramidase, Glucosyl
  • Glucocerebroside beta Glucosidase
  • Glucosyl Hydrolase, Glucosylsphingosine
  • Glucosylceramide beta Glucosidase
  • Hydrolase, Glucosylsphingosine Glucosyl
  • beta Glucocerebrosidase
  • beta-Glucosidase, Acid
  • beta-Glucosidase, Glucocerebroside
  • beta-Glucosidase, Glucosylceramide

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

/defic: consider also GAUCHER DISEASE

MeSH Record

History Note

91(75); was see under GLUCOSIDASES 1975-90

MeSH Record

Previous Indexing

  • Cerebrosides (1970-1974)
  • Glucose (1970-1974)
  • Glycoside Hydrolases (1970-1974)

MeSH Hierarchy

Tree Number

  1. D08.811w.277w.450w.420w.412w

AMA Style

References

  1. National Library of Medicine. Glucosylceramidase. Medical Subject Headings (MeSH). 2026. Unique ID D005962. http://id.nlm.nih.gov/mesh/2026/D005962
  2. Glucosylceramidase. In: Wikipedia. https://en.wikipedia.org/wiki/Glucosylceramidase
  3. Glucosylceramidase. In: Wikidata. https://www.wikidata.org/wiki/Q22032481