Chemicals and Drugs

Glucuronic Acid

A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.

Chemical Identity

Chemical Information

Molecular Formula
C6H10O7
Molecular Weight
194.14 g/mol
CAS Registry No.
576-37-4
IUPAC Name
(2S,3S,4S,5R)-2,3,4,5-tetrahydroxy-6-oxohexanoic acid
InChIKey
IAJILQKETJEXLJ-QTBDOELSSA-N
SMILES
C(=O)[C@@H]([C@H]([C@@H]([C@@H](C(=O)O)O)O)O)O
MeSH Unique ID
D020723
Source
PubChem CID 65041

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

See Also

MeSH Record

Synonyms

8 entry terms
  • Glucuronate
  • Glucuronic Acid, 6-(14)C-labeled, (D)-isomer
  • Glucuronic Acid, Monopotassium Salt
  • Glucuronic Acid, Monosodium Salt
  • Monopotassium Glucuronate
  • Monosodium Glucuronate
  • Glucuronate, Monopotassium
  • Glucuronate, Monosodium

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

for glycoside-linked compounds use GLUCURONIDES

MeSH Record

History Note

2000; for GLUCURONATE use GLUCURONIC ACID 2000-2012

MeSH Record

Previous Indexing

  • Glucuronates (1981-1999)

MeSH Hierarchy

Tree Numbers

  1. D02w.241w.081.844w.915w.162.249w
  2. D02w.241w.152.811w.162.500w
  3. D02w.241w.511w.902w.915w.162.500w
  4. D09w.811w.922w.162.500w

AMA Style

References

  1. National Library of Medicine. Glucuronic Acid. Medical Subject Headings (MeSH). 2026. Unique ID D020723. http://id.nlm.nih.gov/mesh/2026/D020723
  2. Glucuronic Acid. In: Wikipedia. https://en.wikipedia.org/wiki/Glucuronic_acid
  3. Glucuronic Acid. In: Wikidata. https://www.wikidata.org/wiki/Q409216
  4. Glucuronic Acid. In: PubChem Compound. CID 65041. https://pubchem.ncbi.nlm.nih.gov/compound/65041