Chemicals and Drugs

Glutamate Carboxypeptidase II

A metallocarboxypeptidase that is predominantly expressed as a membrane-bound enzyme. It catalyzes the hydrolysis of an unsubstituted, C-terminal glutamyl residue, typically from PTEROYLPOLYGLUTAMIC ACIDS. It was formerly classified as EC 3.4.19.8.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A metallocarboxypeptidase that is predominantly expressed as a membrane-bound enzyme. It catalyzes the hydrolysis of an unsubstituted, C-terminal glutamyl residue, typically from PTEROYLPOLYGLUTAMIC ACIDS. It was formerly classified as EC 3.4.19.8.

MeSH Record

Classification

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MeSH Record

Synonyms

15 entry terms
  • FOLH1 Protein
  • Folate Hydrolase I
  • N-Acetylaspartylglutamate Peptidase
  • N-Acetylated-alpha-Linked Acidic Dipeptidase
  • NAAG Peptidase
  • NAALADase
  • NAALADase II
  • NAALADase L
  • Acidic Dipeptidase, N-Acetylated-alpha-Linked
  • Carboxypeptidase II, Glutamate
  • Dipeptidase, N-Acetylated-alpha-Linked Acidic
  • Hydrolase I, Folate
  • N Acetylaspartylglutamate Peptidase
  • N Acetylated alpha Linked Acidic Dipeptidase
  • Peptidase, N-Acetylaspartylglutamate

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2004; use GLUTAMATE CARBOXYPEPTIDASE II (NM) 1988-2003

MeSH Record

Previous Indexing

  • Carboxypeptidases (1999-2003)
  • Dipeptidases (1988-1998)

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. Glutamate Carboxypeptidase II. Medical Subject Headings (MeSH). 2026. Unique ID D043425. http://id.nlm.nih.gov/mesh/2026/D043425
  2. Glutamate Carboxypeptidase II. In: Wikipedia. https://en.wikipedia.org/wiki/Glutamate_carboxypeptidase_II
  3. Glutamate Carboxypeptidase II. In: Wikidata. https://www.wikidata.org/wiki/Q4140229