Chemicals and Drugs

Glycine Hydroxymethyltransferase

A pyridoxal phosphate enzyme that catalyzes the reaction of glycine and 5,10-methylene-tetrahydrofolate to form serine. It also catalyzes the reaction of glycine with acetaldehyde to form L-threonine. EC 2.1.2.1.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A pyridoxal phosphate enzyme that catalyzes the reaction of glycine and 5,10-methylene-tetrahydrofolate to form serine. It also catalyzes the reaction of glycine with acetaldehyde to form L-threonine. EC 2.1.2.1.

MeSH Record

Classification

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MeSH Record

Synonyms

13 entry terms
  • Allothreonine Aldolase
  • Serine Aldolase
  • Serine Hydroxymethylase
  • Serine Hydroxymethyltransferase
  • Serine Transhydroxymethylase
  • Threonine Aldolase
  • Aldolase, Allothreonine
  • Aldolase, Serine
  • Aldolase, Threonine
  • Hydroxymethylase, Serine
  • Hydroxymethyltransferase, Glycine
  • Hydroxymethyltransferase, Serine
  • Transhydroxymethylase, Serine

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

98(75)

MeSH Record

Previous Indexing

  • Serine (1973-1974)
  • Tetrahydrofolates (1973-1974)
  • Transferases (1973-1974)

MeSH Hierarchy

Tree Number

AMA Style

References

  1. National Library of Medicine. Glycine Hydroxymethyltransferase. Medical Subject Headings (MeSH). 2026. Unique ID D012696. http://id.nlm.nih.gov/mesh/2026/D012696
  2. Glycine Hydroxymethyltransferase. In: Wikipedia. https://en.wikipedia.org/wiki/Serine_hydroxymethyltransferase
  3. Glycine Hydroxymethyltransferase. In: Wikidata. https://www.wikidata.org/wiki/Q24770006