Chemicals and Drugs

Guanethidine

An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.

Chemical Identity

Chemical Information

Molecular Formula
C10H22N4
Molecular Weight
198.31 g/mol
CAS Registry No.
55-65-2
IUPAC Name
2-[2-(azocan-1-yl)ethyl]guanidine
InChIKey
ACGDKVXYNVEAGU-UHFFFAOYSA-N
SMILES
C1CCCN(CCC1)CCN=C(N)N
MeSH Unique ID
D006145
Source
PubChem CID 3518

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

13 entry terms
  • ((2-Hexahydro-1(2H)-azocinyl)ethyl)guanidine
  • Octadine
  • Oktadin
  • Guanethidine Monosulfate
  • Guanethidine Sulfate
  • Guanethidine Sulfate (1:1)
  • Guanethidine Sulfate (1:2)
  • Guanethidine Sulfate (2:1)
  • Guanethidine Sulfate (2:1), 14C-Labeled
  • Ismelin
  • Isobarin
  • Monosulfate, Guanethidine
  • Sulfate, Guanethidine

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Hierarchy

Tree Number

  1. D02w.078w.370.460w

AMA Style

References

  1. National Library of Medicine. Guanethidine. Medical Subject Headings (MeSH). 2026. Unique ID D006145. http://id.nlm.nih.gov/mesh/2026/D006145
  2. Guanethidine. In: Wikipedia. https://en.wikipedia.org/wiki/Guanethidine
  3. Guanethidine. In: Wikidata. https://www.wikidata.org/wiki/Q420673
  4. Guanethidine. In: PubChem Compound. CID 3518. https://pubchem.ncbi.nlm.nih.gov/compound/3518