Chemicals and Drugs

Guanidine

A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.

Chemical Identity

Chemical Information

Molecular Formula
CH5N3
Molecular Weight
59.07 g/mol
CAS Registry No.
113-00-8
IUPAC Name
guanidine
InChIKey
ZRALSGWEFCBTJO-UHFFFAOYSA-N
SMILES
C(=N)(N)N
MeSH Unique ID
D019791
Source
PubChem CID 3520

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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MeSH Record

Synonyms

24 entry terms
  • Guanidinium
  • Guanidine Hydrochloride
  • Guanidine Monohydrate
  • Guanidine Monohydrobromide
  • Guanidine Monohydrochloride
  • Guanidine Monohydroiodine
  • Guanidine Nitrate
  • Guanidine Phosphate
  • Guanidine Sulfate
  • Guanidine Sulfate (1:1)
  • Guanidine Sulfate (2:1)
  • Guanidine Sulfite (1:1)
  • Guanidinium Chloride
  • Guanidium Chloride
  • Chloride, Guanidinium
  • Chloride, Guanidium
  • Hydrochloride, Guanidine
  • Monohydrate, Guanidine
  • Monohydrobromide, Guanidine
  • Monohydrochloride, Guanidine
  • Monohydroiodine, Guanidine
  • Nitrate, Guanidine
  • Phosphate, Guanidine
  • Sulfate, Guanidine

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

98; use GUANIDINE (NM) 1974-97

MeSH Record

Previous Indexing

  • Guanidines (1974-1997)

MeSH Hierarchy

Tree Number

  1. D02w.078w.370.472w

AMA Style

References

  1. National Library of Medicine. Guanidine. Medical Subject Headings (MeSH). 2026. Unique ID D019791. http://id.nlm.nih.gov/mesh/2026/D019791
  2. Guanidine. In: Wikipedia. https://en.wikipedia.org/wiki/Guanidine
  3. Guanidine. In: Wikidata. https://www.wikidata.org/wiki/Q183309
  4. Guanidine. In: PubChem Compound. CID 3520. https://pubchem.ncbi.nlm.nih.gov/compound/3520