Structured Summary
Abstract
A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the presence of Mg2+. The nucleotide is a potent stimulator of ADENYLYL CYCLASES.
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Synonyms
8 entry terms
- GMP-P(NH)P
- GMP-PNP
- Gpp(NH)p
- Guanosine 5'-(Beta,Gamma-Imido)Triphosphate
- Guanyl-5'-Imidodiphosphate
- P(NH)PPG
- Guanyl 5' Imidodiphosphate
- Imidodiphosphate, Guanylyl
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Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
91(78); was see under GUANOSINE TRIPHOSPHATE 1978-90
MeSH Record
Previous Indexing
- Guanine Nucleotides (1966-1977)
- Guanosine Triphosphate (1972-1977)
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AMA Style
References
- National Library of Medicine. Guanylyl Imidodiphosphate. Medical Subject Headings (MeSH). 2026. Unique ID D006165. http://id.nlm.nih.gov/mesh/2026/D006165
- Guanylyl Imidodiphosphate. In: Wikipedia. https://en.wikipedia.org/wiki/5%27-Guanylyl_imidodiphosphate
- Guanylyl Imidodiphosphate. In: Wikidata. https://www.wikidata.org/wiki/Q4639534