Structured Summary
Abstract
A component of CRISPR-Cas SYSTEMS. Cas endodeoxyribonucleases assemble with a guide RNA complex, a hybrid of CRISPR RNA (crRNA) and transactivating crRNA (tracrRNA) molecules, to form an active complex that cleaves DNA. crRNA and tracrRNA can be synthetically fused into a single RNA molecule, namely single guide RNA. Synthetic sgRNA is used with CRISPR-Cas SYSTEMS for targeted GENE EDITING.
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Synonyms
20 entry terms
- Guide RNA (CRISPR-Cas Systems)
- Guide RNA, CRISPR-Cas Systems
- RNA, Guide (CRISPR-Cas Systems)
- RNA, Guide, CRISPR-Cas Systems
- Guide RNA, CRISPR Cas Systems
- CRISPR Guide RNA
- CRISPR-Cas Systems sgRNA (Single Guide RNA)
- RNA, CRISPR Guide
- RNA, Single Guide
- RNA, Single-Guide
- Single Guide RNA
- Single-Guide RNA
- Transactivating crRNA
- crRNA
- crRNA, Transactivating
- sgRNA (CRISPR-Cas Systems)
- sgRNA (Single-Guide RNA)
- tracrRNA
- Guide RNA, CRISPR
- Guide RNA, Single
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Aspects Covered
31 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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Indexing Annotation
do not confuse with RNA, GUIDE, KINETOPLASTIDA; do not confuse sgRNA (SINGLE-GUIDE RNA) with sgRNA (SUBGENOMIC RNA)
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History Note
2023
MeSH Record
Previous Indexing
- CRISPR-Cas Systems (2014-2022)
- RNA, Guide, CRISPR-Cas Systems (2008-2022)
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AMA Style
References
- National Library of Medicine. Guide CRISPR-Cas Systems RNA. Medical Subject Headings (MeSH). 2026. Unique ID D000094704. http://id.nlm.nih.gov/mesh/2026/D000094704
- Guide CRISPR-Cas Systems RNA. In: Wikidata. https://www.wikidata.org/wiki/Q116847642