Chemicals and Drugs

Heat Shock Transcription Factors

Heat and cold stress-inducible, transcription factors that bind to inverted 5'-NGAAN-3' pentamer DNA sequences and are regulated by POLY-ADP-RIBOSYLATION. They play essential roles as transcriptional activators of the HEAT-SHOCK RESPONSE by inducing expression of large classes of MOLECULAR CHAPERONES and heat-shock proteins. They also function in DNA REPAIR; transcriptional reactivation of latent HIV-1; and pre-mRNA processing and nuclear export of HSP70 HEAT-SHOCK PROTEINS during heat stress.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Heat and cold stress-inducible, transcription factors that bind to inverted 5'-NGAAN-3' pentamer DNA sequences and are regulated by POLY-ADP-RIBOSYLATION. They play essential roles as transcriptional activators of the HEAT-SHOCK RESPONSE by inducing expression of large classes of MOLECULAR CHAPERONES and heat-shock proteins. They also function in DNA REPAIR; transcriptional reactivation of latent HIV-1; and pre-mRNA processing and nuclear export of HSP70 HEAT-SHOCK PROTEINS during heat stress.

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Synonyms

8 entry terms
  • Heat Shock Transcription Factor
  • Heat Shock Factor Protein 1
  • Heat Shock Factor, Plant
  • Heat Shock Transcription Factor 1
  • Heat Stress Transcription Factor
  • Heat Stress Transcription Factors
  • Plant Heat Shock Factor
  • Plant Heat Shock Factors

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Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018 (1992)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.687.450w
  2. D12.776w.260w.260w
  3. D12.776w.660w.720.462w
  4. D12.776w.930w.317w

AMA Style

References

  1. National Library of Medicine. Heat Shock Transcription Factors. Medical Subject Headings (MeSH). 2026. Unique ID D000076249. http://id.nlm.nih.gov/mesh/2026/D000076249
  2. Heat Shock Transcription Factors. In: Wikipedia. https://en.wikipedia.org/wiki/Heat_shock_factor
  3. Heat Shock Transcription Factors. In: Wikidata. https://www.wikidata.org/wiki/Q24782817