Anatomy

Hemidesmosomes

An anchoring junction of the cell to a non-cellular substrate, similar in morphology to halves of DESMOSOMES. They are composed of specialized areas of the plasma membrane where INTERMEDIATE FILAMENTS bind on the cytoplasmic face to the transmembrane linkers, INTEGRINS, via intracellular attachment proteins, while the extracellular domain of the integrins binds to EXTRACELLULAR MATRIX PROTEINS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An anchoring junction of the cell to a non-cellular substrate, similar in morphology to halves of DESMOSOMES. They are composed of specialized areas of the plasma membrane where INTERMEDIATE FILAMENTS bind on the cytoplasmic face to the transmembrane linkers, INTEGRINS, via intracellular attachment proteins, while the extracellular domain of the integrins binds to EXTRACELLULAR MATRIX PROTEINS.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

1 entry terms
  • Hemidesmosome

MeSH Record

Aspects Covered

15 allowable subheadings

Indexed with the subheadings chemistry, classification, drug effects, enzymology, genetics, immunology, metabolism, microbiology, parasitology, pathology, physiology, radiation effects, transplantation, ultrastructure, virology.

MeSH Record

History Note

2001

MeSH Record

Previous Indexing

  • Desmosomes (1972-2000)

MeSH Hierarchy

Tree Number

  1. A11w.284w.149w.165.165.360w

AMA Style

References

  1. National Library of Medicine. Hemidesmosomes. Medical Subject Headings (MeSH). 2026. Unique ID D022002. http://id.nlm.nih.gov/mesh/2026/D022002
  2. Hemidesmosomes. In: Wikipedia. https://en.wikipedia.org/wiki/Hemidesmosome
  3. Hemidesmosomes. In: Wikidata. https://www.wikidata.org/wiki/Q1604780