Diseases

Hereditary Nonpolyposis Colorectal Neoplasms

A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.

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Synonyms

14 entry terms
  • Colorectal Neoplasms, Hereditary Nonpolyposis
  • Familial Nonpolyposis Colon Cancer
  • Colon Cancer, Familial Nonpolyposis
  • Colon Cancer, Familial Nonpolyposis, Type 1
  • Colorectal Cancer Hereditary Nonpolyposis
  • Colorectal Cancer, Hereditary Nonpolyposis, Type 1
  • Familial Nonpolyposis Colon Cancer Type 1
  • Hereditary Nonpolyposis Colon Cancer
  • Hereditary Nonpolyposis Colorectal Cancer
  • Hereditary Nonpolyposis Colorectal Cancer Type 1
  • Lynch Cancer Family Syndrome I
  • Lynch Syndrome
  • Lynch Syndrome I
  • Syndrome, Lynch

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Aspects Covered

38 allowable subheadings

Indexed with the subheadings blood, blood supply, cerebrospinal fluid, chemically induced, chemistry, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, secondary, surgery, therapy, ultrastructure, urine, veterinary, virology.

MeSH Record

History Note

87

MeSH Hierarchy

Tree Numbers

  1. C04w.588.274.476.411w.307.190w
  2. C04w.700w.250w
  3. C06w.301.371.411w.307.190w
  4. C06w.405w.249.411w.307.190w
  5. C06w.405w.469w.158.356.190w
  6. C06w.405w.469w.491w.307.190w
  7. C16w.320w.700w.250w
  8. C18.452w.284w.255w

MeSH Record

NLM Classification

WI 529

AMA Style

References

  1. National Library of Medicine. Hereditary Nonpolyposis Colorectal Neoplasms. Medical Subject Headings (MeSH). 2026. Unique ID D003123. http://id.nlm.nih.gov/mesh/2026/D003123
  2. Hereditary Nonpolyposis Colorectal Neoplasms. In: Wikipedia. https://en.wikipedia.org/wiki/Hereditary_nonpolyposis_colorectal_cancer
  3. Hereditary Nonpolyposis Colorectal Neoplasms. In: Wikidata. https://www.wikidata.org/wiki/Q783644