Chemicals and Drugs

High-Temperature Requirement A Serine Peptidase 2

A serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE.

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Synonyms

13 entry terms
  • HtrA Serine Peptidase 2
  • HtrA2 Protease
  • Omi Serine Protease
  • Serine Protease HTRA2
  • Serine Protease Omi
  • HTRA2, Serine Protease
  • High Temperature Requirement A Serine Peptidase 2
  • Omi, Serine Protease
  • Protease HTRA2, Serine
  • Protease Omi, Serine
  • Protease, HtrA2
  • Protease, Omi Serine
  • Serine Protease, Omi

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018 (2000)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.656w.300w.760.431
  2. D08.811w.277w.656w.959w.350.431
  3. D12.776w.476.075.429
  4. D12.776w.575.656
  5. D12.776w.705.625

AMA Style

References

  1. National Library of Medicine. High-Temperature Requirement A Serine Peptidase 2. Medical Subject Headings (MeSH). 2026. Unique ID D000074923. http://id.nlm.nih.gov/mesh/2026/D000074923
  2. High-Temperature Requirement A Serine Peptidase 2. In: Wikidata. https://www.wikidata.org/wiki/Q21111681