Chemicals and Drugs

Histamine H2 Antagonists

Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

See Also

MeSH Record

Synonyms

25 entry terms
  • Antagonists, Histamine H2
  • Antihistaminics, H2
  • Blockaders, Histamine H2 Receptor
  • H2 Receptor Blockader
  • H2 Receptor Blockaders
  • Histamine H2 Antagonist
  • Histamine H2 Blocker
  • Histamine H2 Blockers
  • Histamine H2 Receptor Antagonist
  • Histamine H2 Receptor Antagonists
  • Histamine H2 Receptor Blockader
  • Histamine H2 Receptor Blockaders
  • Receptor Antagonists, Histamine H2
  • Receptor Blockaders, H2
  • Antagonist, Histamine H2
  • Blockader, H2 Receptor
  • Blockaders, H2 Receptor
  • Blocker, Histamine H2
  • Blockers, Histamine H2
  • H2 Antagonist, Histamine
  • H2 Antagonists, Histamine
  • H2 Antihistaminics
  • H2 Blocker, Histamine
  • H2 Blockers, Histamine
  • Receptor Blockader, H2

MeSH Record

Aspects Covered

22 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

95; was HISTAMINE H2 RECEPTOR BLOCKADERS 1977-94

MeSH Hierarchy

Tree Numbers

  1. D27.505.519w.625.375w.425w.425w
  2. D27.505.696.577.375w.425w.425w

MeSH Record

NLM Classification

QV 157

AMA Style

References

  1. National Library of Medicine. Histamine H2 Antagonists. Medical Subject Headings (MeSH). 2026. Unique ID D006635. http://id.nlm.nih.gov/mesh/2026/D006635
  2. Histamine H2 Antagonists. In: Wikipedia. https://en.wikipedia.org/wiki/H2_receptor_antagonist
  3. Histamine H2 Antagonists. In: Wikidata. https://www.wikidata.org/wiki/Q409444