Structured Summary
Abstract
A class II histone deacetylase that removes acetyl groups from N-terminal LYSINES of HISTONE H2A; HISTONE H2B; HISTONE H3; and HISTONE H4. It plays a critical role in EPIGENETIC REPRESSION and regulation of GENETIC TRANSCRIPTION, as well as CELL MOTILITY through deacetylation of TUBULIN. It also targets misfolded proteins for clearance by AUTOPHAGY when MOLECULAR CHAPERONE-mediated folding is overwhelmed.
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29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
2018
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Previous Indexing
- Histone Deacetylases (2001-2017)
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References
- National Library of Medicine. Histone Deacetylase 6. Medical Subject Headings (MeSH). 2026. Unique ID D000073864. http://id.nlm.nih.gov/mesh/2026/D000073864
- Histone Deacetylase 6. In: Wikidata. https://www.wikidata.org/wiki/Q21173381