Structured Summary
Abstract
Homer proteins belong to a family of adaptor and scaffold proteins which include Homer1, Homer2 and Homer3. Homer1 and Homer2 play a role in the regulation of calcium homeostasis, whereas Homer3 functions in stimulating changes in actin dynamics in neurons and T-cells. Homer proteins are best known as scaffold proteins at the post-synaptic density where they facilitate synaptic signaling. They function as a molecular switch in metabotropic glutamate receptor (MGluR) signaling, and are associated with human Fragile X syndrome.
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Classification
Broader headings
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Synonyms
19 entry terms
- Homer Protein
- Homer Proteins
- Protein, Homer
- Proteins, Homer
- Proteins, Homer Scaffolding
- Scaffolding Proteins, Homer
- Homer 1
- Homer 1 Proteins
- Homer 1C
- Homer 1C Proteins
- Homer 1a
- Homer 2
- Homer 2 Proteins
- Homer 3
- Homer 3 Proteins
- Proteins, Homer 1
- Proteins, Homer 1C
- Proteins, Homer 2
- Proteins, Homer 3
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2017 (1997)
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AMA Style
References
- National Library of Medicine. Homer Scaffolding Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D000072233. http://id.nlm.nih.gov/mesh/2026/D000072233
- Homer Scaffolding Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q58622821