Chemicals and Drugs

Hydrochlorothiazide

A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.

Chemical Identity

Chemical Information

Molecular Formula
C7H8ClN3O4S2
Molecular Weight
297.7 g/mol
CAS Registry No.
58-93-5
IUPAC Name
6-chloro-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
InChIKey
JZUFKLXOESDKRF-UHFFFAOYSA-N
SMILES
C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl
MeSH Unique ID
D006852
Source
PubChem CID 3639

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • Dichlothiazide
  • Dihydrochlorothiazide
  • HCTZ
  • Esidrex
  • Esidrix
  • HydroDIURIL
  • Hypothiazide
  • Oretic
  • Sectrazide

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Hierarchy

Tree Numbers

  1. D02w.886w.590w.700w.135.261w.476w
  2. D02w.886w.655w.500.261w.476w
  3. D03w.633.100.174.261w.476w

MeSH Record

NLM Classification

QV 160

AMA Style

References

  1. National Library of Medicine. Hydrochlorothiazide. Medical Subject Headings (MeSH). 2026. Unique ID D006852. http://id.nlm.nih.gov/mesh/2026/D006852
  2. Hydrochlorothiazide. In: Wikipedia. https://en.wikipedia.org/wiki/Hydrochlorothiazide
  3. Hydrochlorothiazide. In: Wikidata. https://www.wikidata.org/wiki/Q423930
  4. Hydrochlorothiazide. In: PubChem Compound. CID 3639. https://pubchem.ncbi.nlm.nih.gov/compound/3639