Chemicals and Drugs

Hydrocortisone

The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.

Chemical Identity

Chemical Information

Molecular Formula
C21H30O5
Molecular Weight
362.5 g/mol
CAS Registry No.
50-23-7
IUPAC Name
(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
InChIKey
JYGXADMDTFJGBT-VWUMJDOOSA-N
SMILES
C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O
MeSH Unique ID
D006854
Source
PubChem CID 5754

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

10 entry terms
  • Cortisol
  • Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-
  • 11-Epicortisol
  • Cortef
  • Cortifair
  • Cortril
  • Epicortisol
  • Hydrocortisone, (11 alpha)-Isomer
  • Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer
  • 11 Epicortisol

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

/adv eff-pois-tox was HYDROCORTISONE TOXICOLOGY 1963-65

MeSH Hierarchy

Tree Numbers

  1. D04w.210.500w.745.745w.654w.600w
  2. D06.472w.040.585w.353.476w
  3. D06.472w.040.585w.478.392w

AMA Style

References

  1. National Library of Medicine. Hydrocortisone. Medical Subject Headings (MeSH). 2026. Unique ID D006854. http://id.nlm.nih.gov/mesh/2026/D006854
  2. Hydrocortisone. In: Wikipedia. https://en.wikipedia.org/wiki/Cortisol
  3. Hydrocortisone. In: Wikidata. https://www.wikidata.org/wiki/Q190875
  4. Hydrocortisone. In: PubChem Compound. CID 5754. https://pubchem.ncbi.nlm.nih.gov/compound/5754