Chemicals and Drugs

Hydroxyacylglutathione Hydrolase

A thiolesterase that catalyzes the production of GLUTATHIONE and D-LACTIC ACID from the hydrolysis of S-D-lactoyl-glutathione. In vertebrates, only one gene that encodes hydroxyacylglutathione hydrolase is known to occur. In yeast and higher plants, separate genes encode the cytosolic and mitochondrial forms of this enzyme.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A thiolesterase that catalyzes the production of GLUTATHIONE and D-LACTIC ACID from the hydrolysis of S-D-lactoyl-glutathione. In vertebrates, only one gene that encodes hydroxyacylglutathione hydrolase is known to occur. In yeast and higher plants, separate genes encode the cytosolic and mitochondrial forms of this enzyme.

MeSH Record

Classification

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MeSH Record

Synonyms

5 entry terms
  • Acetoacetylglutathione Hydrolase
  • Glo2 Hydrolase Enzyme
  • Glyoxalase II
  • HAGH Protein
  • Hydroxyacyl Glutathione Hydrolase

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2026 (1973)

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AMA Style

References

  1. National Library of Medicine. Hydroxyacylglutathione Hydrolase. Medical Subject Headings (MeSH). 2026. Unique ID D000099301. http://id.nlm.nih.gov/mesh/2026/D000099301
  2. Hydroxyacylglutathione Hydrolase. In: Wikipedia. https://en.wikipedia.org/wiki/Hydroxyacylglutathione_hydrolase
  3. Hydroxyacylglutathione Hydrolase. In: Wikidata. https://www.wikidata.org/wiki/Q10507666