Diseases

Hyper-IgM Immunodeficiency Syndrome

A rare inherited immunodeficiency syndrome characterized by normal or elevated serum IMMUNOGLOBULIN M levels with absence of IMMUNOGLOBULIN G; IMMUNOGLOBULIN A; and IMMUNOGLOBULIN E. It results in a profound susceptibility to BACTERIAL INFECTIONS and an increased susceptibility to OPPORTUNISTIC INFECTIONS. Several subtypes of hyper-IgM immunodeficiency syndrome exist depending upon the location of genetic mutation.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A rare inherited immunodeficiency syndrome characterized by normal or elevated serum IMMUNOGLOBULIN M levels with absence of IMMUNOGLOBULIN G; IMMUNOGLOBULIN A; and IMMUNOGLOBULIN E. It results in a profound susceptibility to BACTERIAL INFECTIONS and an increased susceptibility to OPPORTUNISTIC INFECTIONS. Several subtypes of hyper-IgM immunodeficiency syndrome exist depending upon the location of genetic mutation.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

42 entry terms
  • Hyper-IgM Syndrome
  • Immunodeficiency with Hyper-IgM Syndrome
  • Hyper IgM Immunodeficiency Syndrome
  • Hyper IgM Syndrome
  • Hyper-IgM Immunodeficiency Syndromes
  • Hyper-IgM Syndromes
  • Immunodeficiency Syndrome, Hyper-IgM
  • Immunodeficiency Syndromes, Hyper-IgM
  • Immunodeficiency with Hyper IgM Syndrome
  • Syndrome, Hyper-IgM Immunodeficiency
  • Syndromes, Hyper-IgM Immunodeficiency
  • HIGM2 Syndrome
  • HIGM3 Syndrome
  • HIGM5 Syndrome
  • Hyper-IgM Immunodeficiency Syndrome Type 2
  • Hyper-IgM Immunodeficiency Syndrome Type 3
  • Hyper-IgM Immunodeficiency Syndrome Type 5
  • Hyper-IgM Immunodeficiency Syndrome, Type 2
  • Hyper-IgM Immunodeficiency Syndrome, Type 3
  • Hyper-IgM Immunodeficiency Syndrome, Type 5
  • Hyper-IgM Syndrome 2
  • Hyper-IgM Syndrome 3
  • Hyper-IgM Syndrome 5
  • Immunodeficiency with Hyper-IgM, Type 2
  • Immunodeficiency with Hyper-IgM, Type 3
  • Immunodeficiency with Hyper-IgM, Type 5
  • HIGM2 Syndromes
  • HIGM3 Syndromes
  • HIGM5 Syndromes
  • Hyper IgM Immunodeficiency Syndrome Type 2
  • Hyper IgM Immunodeficiency Syndrome Type 3
  • Hyper IgM Immunodeficiency Syndrome Type 5
  • Hyper IgM Immunodeficiency Syndrome, Type 2
  • Hyper IgM Immunodeficiency Syndrome, Type 3
  • Hyper IgM Immunodeficiency Syndrome, Type 5
  • Hyper IgM Syndrome 2
  • Hyper IgM Syndrome 3
  • Hyper IgM Syndrome 5
  • Hyper-IgM Syndrome 5s
  • Immunodeficiency with Hyper IgM, Type 2
  • Immunodeficiency with Hyper IgM, Type 3
  • Immunodeficiency with Hyper IgM, Type 5

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

2007

MeSH Record

Previous Indexing

  • Immunoglobulin A (1995-2006)
  • Immunoglobulin E (1995-2006)
  • Immunoglobulin G (1995-2006)
  • Immunoglobulin M (1995-2006)
  • Immunologic Deficiency Syndromes (1995-2006)

MeSH Hierarchy

Tree Numbers

  1. C15.378w.147.333w.249w
  2. C16w.320w.413w
  3. C16w.320w.798w.625w
  4. C20w.673w.430w.250w
  5. C20w.673w.795w.625w

AMA Style

References

  1. National Library of Medicine. Hyper-IgM Immunodeficiency Syndrome. Medical Subject Headings (MeSH). 2026. Unique ID D053306. http://id.nlm.nih.gov/mesh/2026/D053306
  2. Hyper-IgM Immunodeficiency Syndrome. In: Wikipedia. https://en.wikipedia.org/wiki/Hyper_IgM_syndrome
  3. Hyper-IgM Immunodeficiency Syndrome. In: Wikidata. https://www.wikidata.org/wiki/Q1617658