Chemicals and Drugs

Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

A subgroup of cyclic nucleotide-regulated ION CHANNELS of the superfamily of pore-loop cation channels that are opened by hyperpolarization rather than depolarization. The ion conducting pore passes SODIUM, CALCIUM, and POTASSIUM cations with a preference for potassium.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A subgroup of cyclic nucleotide-regulated ION CHANNELS of the superfamily of pore-loop cation channels that are opened by hyperpolarization rather than depolarization. The ion conducting pore passes SODIUM, CALCIUM, and POTASSIUM cations with a preference for potassium.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

36 entry terms
  • HCN Pacemaker Channels
  • Hyperpolarization Cyclic-Nucleotide Gated Ion Channels
  • Hyperpolarization-Activated Cation Channel
  • I(h) Cation Channels
  • I(h) Channels
  • Ih Cation Channels
  • Cation Channel, Hyperpolarization-Activated
  • Cation Channels, Ih
  • Channel, Hyperpolarization-Activated Cation
  • Channels, HCN Pacemaker
  • Channels, Ih Cation
  • Hyperpolarization Activated Cation Channel
  • Hyperpolarization Activated Cyclic Nucleotide Gated Channels
  • Hyperpolarization Cyclic Nucleotide Gated Ion Channels
  • Pacemaker Channels, HCN
  • HCN1 Channel
  • HCN2 Channel
  • HCN2 Potassium Channel
  • HCN3 Channel
  • HCN4 Channel
  • Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2
  • Hyperpolarization Cyclic-Nucleotide Gated Cation Channel 1
  • Hyperpolarization Cyclic-Nucleotide Gated Cation Channel 3
  • Hyperpolarization Cyclic-Nucleotide Gated Cation Channel 4
  • Potassium-Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2
  • Channel, HCN1
  • Channel, HCN2
  • Channel, HCN2 Potassium
  • Channel, HCN3
  • Channel, HCN4
  • Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 2
  • Hyperpolarization Cyclic Nucleotide Gated Cation Channel 1
  • Hyperpolarization Cyclic Nucleotide Gated Cation Channel 3
  • Hyperpolarization Cyclic Nucleotide Gated Cation Channel 4
  • Potassium Channel, HCN2
  • Potassium Sodium Hyperpolarization Activated Cyclic Nucleotide Gated Channel 2

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2014

MeSH Record

Previous Indexing

  • Cyclic Nucleotide-Gated Cation Channels (2001-2013)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.530w.400w.368w
  2. D12.776w.543w.550w.450w.476w
  3. D12.776w.543w.585w.400w.476w

AMA Style

References

  1. National Library of Medicine. Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels. Medical Subject Headings (MeSH). 2026. Unique ID D064428. http://id.nlm.nih.gov/mesh/2026/D064428
  2. Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels. In: Wikipedia. https://en.wikipedia.org/wiki/HCN_channel
  3. Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels. In: Wikidata. https://www.wikidata.org/wiki/Q3459035