Structured Summary
Abstract
Methylene cyclopropyl alanine and congeners isolated from the unripe edible fruit of the AKEE plant (BLIGHIA SAPIDA). Hypoglycin B is the gamma-glutamyl congener of hypoglycin A. They are very toxic and teratogenic, causing a syndrome called Jamaican vomiting sickness that includes a fall in blood glucose due to the interference of FATTY ACIDS and LEUCINE metabolism which leads to VOMITING, liver damage, CONVULSIONS and DEATH.
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Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
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Indexing Annotation
Jamaican vomiting sickness : coordinate HYPOGLYCINS /pois (IM) with PLANT POISONING (IM)
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History Note
91(77); was see under CYCLOPROPANES 1977-90
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Previous Indexing
- Alanine (1973-1976)
- Cyclopropanes (1970-1976)
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References
- National Library of Medicine. Hypoglycins. Medical Subject Headings (MeSH). 2026. Unique ID D007005. http://id.nlm.nih.gov/mesh/2026/D007005
- Hypoglycins. In: Wikidata. https://www.wikidata.org/wiki/Q76613125