Chemicals and Drugs

IFIH1 Interferon-Induced Helicase

A DEAD box RNA helicase that contains two N-terminal CASPASE ACTIVATION AND RECRUITMENT DOMAINS. It functions as a sensor of viral NUCLEIC ACIDS such as DOUBLE-STRANDED RNA and activates the INNATE IMMUNE RESPONSE by inducing the expression of INTERFERON-ALPHA and INTERFERON-BETA. It may also regulate cell growth and APOPTOSIS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A DEAD box RNA helicase that contains two N-terminal CASPASE ACTIVATION AND RECRUITMENT DOMAINS. It functions as a sensor of viral NUCLEIC ACIDS such as DOUBLE-STRANDED RNA and activates the INNATE IMMUNE RESPONSE by inducing the expression of INTERFERON-ALPHA and INTERFERON-BETA. It may also regulate cell growth and APOPTOSIS.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

13 entry terms
  • CADM-140 Autoantigen
  • Helicard
  • IFIH1 Protein
  • Interferon Induced with Helicase C Domain 1
  • Interferon-Induced Helicase C Domain-Containing Protein 1
  • Interferon-Induced Helicase, IFIH1
  • Melanoma Differentiation-Associated Protein 5
  • Autoantigen, CADM-140
  • CADM 140 Autoantigen
  • Helicase, IFIH1 Interferon-Induced
  • Interferon Induced Helicase C Domain Containing Protein 1
  • Interferon Induced Helicase, IFIH1
  • Melanoma Differentiation Associated Protein 5

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • DEAD-box RNA Helicases (2006-2016)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.445w.735.720w.249.875w
  2. D12.776w.066.125w

AMA Style

References

  1. National Library of Medicine. IFIH1 Interferon-Induced Helicase. Medical Subject Headings (MeSH). 2026. Unique ID D000072640. http://id.nlm.nih.gov/mesh/2026/D000072640
  2. IFIH1 Interferon-Induced Helicase. In: Wikipedia. https://en.wikipedia.org/wiki/MDA5
  3. IFIH1 Interferon-Induced Helicase. In: Wikidata. https://www.wikidata.org/wiki/Q21111069